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Physiol Rev 94:329354 Bianchi G, Caporali R, Todoerti M, Mattana P (2016) Methotrexate and rheumatoid arthritis: current evidence regarding subcutaneous versus oral routes of administration

The blend is well tolerated, with gastrointestinal effects being the most frequent adverse events and no evidence of clinically significant safety concerns or neutralizing antibody responses to cagrilintide during short-term exposure 1-3