DBS eliminate the need of specialized personnel (phlebotomist) at the collection site, reduce sample collection invasiveness, and facilitate transport and storage by decreasing the associated logistics [ 3,4]
UA activates the inflammatory response of tissue-intrinsic cells indirectly affecting immune cells MSU crystals activate the TLR4/NF-B/NLRP3 signaling pathway in human umbilical vein endothelial cells (HUVECs), leading to the secretion of intercellular cell adhesion molecule-1 (ICAM-1), IL-1, IL-6, and vascular cellular adhesion molecule-1 (VCAM-1)
A lot of evidence has shown that excessive activation of NMDARs in AD is related to changes in the expression of calpain, Ca 2+ /CaMKII, GSK-3, and other proteins, which play crucial roles in excitotoxicity and neurodegeneration [151]
10.1111/nyas.13930 136 SkoutaR.DixonS