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Notably, oxPLs can directly engage TLR4 on fibroblasts, initiating downstream TGF- and NF-B signaling pathways that reinforce fibroblast activation and survival (116)

Lee JM, Yanagawa J, Peebles KA, Sharma S, Mao JT, Dubinett SM

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Contraindications and High-Risk Situations Sermorelin carries absolute contraindications that apply with particular force in the adolescent population: Active intracranial neoplasm: Any adolescent with a current or recent brain tumor, including craniopharyngioma or pituitary adenoma, must not receive sermorelin without explicit clearance from their neuro-oncology and endocrinology teams