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doi: 10.1186/ar2396 [DOI] [PMC free article] [PubMed] [Google Scholar] 161.Zheng SC, Zhu XX, Xue Y, et al

However, if a deficiency developed during treatment, it will not self-correct just because the medication stopped

However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)