Heres how it works: Usually, the root cause of HPA axis dysfunction is inflammation due to a variety of stressors, including emotional stress (at home or work), undiagnosed infections, exposure to environmental toxins and pollutants, food sensitivities or poor diet
Expert Rev Hematol
Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) such as isoprostanes (IsoPs), neuroprotanes, malondialdehyde, unsaturated aldehydes including 4-hydroxy-2- trans -nonenal (HNE), 4-hydroxy-2- trans -hexenal (HHE), and 2-propenal (acrolein), with different degrees of reactivity (Porter et al., Clearly, the concurrency of these factors in the presence of high amounts of polyunsaturated fatty acids, mainly DHA, is expected to favor the free radical-induced peroxidation of DHA in the brain parenchyma (Van Kuijk et al., Nerve cells are endowed with different antioxidant systems that render them protected from oxidative damage caused by lipid peroxides
PMID: 126 Picchianti-DiamantiAPanebiancoCSalemiSSorgiMDi RosaRTropeaAet al