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Institutional Review Boards (IRBs) IRBs review clinical trial protocols before clinical trials can accept patients

Nature 573 , 6168 (2019)

Obstet Gynecol 116:11711183 Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, Green DM, Armstrong GT, Nottage KA, Jones KE et al (2013) Clinical ascertainment of health outcomes among adults treated for childhood cancer

To illustrate this point specifically, IBS patients were found to be absent from work 2 days/month on average, with reduced work productivity for 9 days/month, according to a report ( The fecal microbiota of IBS patients has been known to exhibit several qualitative and quantitative alterations (Klem et al., 2017)