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The mitogen-activated protein kinases (MAPKs) family, including extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun NH2-terminal kinase (JNK1/2), has been shown to play a significant role in the mediation of signals triggered by cytokines, growth factors, and environmental stress and is involved in various cellular functions [9, 10]

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ABSTRACT: Fibromyalgia, a condition affecting the central nervous system, causes widespread pain as well as other symptomssuch as sleep disruptions, fatigue, and difficulty concentratingthat adversely affect the patients quality of life

Statistical analysis The results are presented as mean SD from at least three independent biological replicates, with all analyses performed using GraphPad Prism 7 (GraphPad Software, USA)