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In the SUMMIT trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

All mice were sacrificed after 12 weeks of CS exposure or air exposure

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Do not administer to animals with diarrhea