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Tsao AS, Harun N, Fujimoto J, Devito V, Lee JJ, Kuhn E, Mehran R, Rice D, Moran C, Hong WK, Shen L, Suraokar M, Wistuba I

Pathogen eradication with antibiotics became the norm and dominated 20th-century medicine along with a focus on psychopharmacology as chemical imbalance-based theories of depression gained ground in the 1950s and 1960s.12 During this time, Ren Dubos, PhD, and other highly respected microbiologists again proposed that the noxious components produced by intestinal flora impacted ones physical and mental well-being

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At the molecular level, it appears to interact with intracellular signaling systems essential for tissue adaptation