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introducing high doses of glutathione too rapidly can occasionally trigger a "Herxheimer" or detoxification reaction, where the sudden mobilization of stored toxins temporarily exacerbates symptoms like fatigue, brain fog, or mild nausea

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doi: 10.1691/ph.2018.8650 26 DuX

J Experimental Clin Cancer Res 40:19 Shirjang S, Mansoori B, Asghari S, Duijf PHG, Mohammadi A, Gjerstorff M, Baradaran B (2019) MicroRNAs in cancer cell death pathways: apoptosis and necroptosis