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In contrast, rats supplemented with the active form of vitamin D, 1,25(OH)D, showed restored LTP responses following tetanic stimulation, suggesting that vitamin D supports synaptic plasticity by preserving postsynaptic responsiveness under neurotoxic conditions (78)

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333 AG-270 is an oral selective MAT2A inhibitor that selectively inhibits the proliferation of MTAP null cells and effectively reduces the level of SAM in tumor cells in tissue and xenograft tumor models