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During the first 4 h after LPS administration, the percentage of monocytes ( Figure 2F ) decreased by 90% with a large animal-specific variation to the mean nadir, followed by a slight increase until the end of the study

While lactate impairs the motility and cytolytic function of effector CD8 + T cells, it does not inhibit glycolysis in these cells, unlike in CD4 + T cells, yet still compromises their mobility, thus blunting their cytolytic function [116]