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Arthroplasty, 37 (2022): pp.23582364

Importantly, the selective effect of metformin on mutant CMs, while sparing healthy and isogenic control CMs, suggests that metformin could be a promising therapeutic agent for PRKAG2 cardiomyopathy

Clinical research indicates that the most effective daily dosage for NAD+ precursors (such as nicotinamide riboside or nicotinamide mononucleotide) typically falls within the range of 250 milligrams to 500 milligrams per day for most adults, though some studies safely use up to 1,000mg per day for more robust increases in NAD+ levels

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