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TB-500 is commonly discussed as a synthetic fragment related to thymosin beta-4, a naturally occurring peptide involved in cell migration, actin regulation, and wound-healing biology

Hydrogen peroxide stimulates the synthesis of platelet activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion

Several studies have shown that anti-EpCAM antibodies limit therapeutic efficacies as the results of showing dose- and target-dependent in metastatic cancers, short serum half-life, altered EpCAM expression pattern, and differential cleavage and localization of EpICD in cancer cells (Fig