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Chronic hypoxia-induced -syn pathology and cognitive impairment in mice remain irreversible after reoxygenation We have found that chronic hypoxia promoted the abnormal pathology of -syn through an HIF-2-dependent pathway, which is an important link in inducing neuronal injury and cognitive impairment in mice

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The difference between the groups increased when evaluated at d 56 (28 d following last dose) at which point the mean improvement in the ARA 290 had increased to 4.2, and the placebo group diminished to 0.74 points

Interaction between A and tau in the pathogenesis of Alzheimers disease