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If methylation is sluggish (often for genetic reasons) or the body doesn't have enough nutrients (including vitamin B12 and folate) to turn the methylation cycle, the body can't make enough glutathione

J Phys Chem B 115(45):1340813417 Hsu C-c, Huang C-n, Hung Y-c, Yin M-c (2004) Five cysteine-containing compounds have antioxidative activity in Balb/cA mice

Alterations in Rac1 activity were also affected by several autism-risk gene mutations, including fragile X mental retardation 1 (Fmr1), neurexin 1 (Nrx1), neuroligin 4 (Nlg4), and tuberous sclerosis 1 (Tsc1)

This imbalance is believed to be manifested in most brain regions, including the amygdala, cortex, and hippocampus, and plays a central role in several pathological conditions, such as Fragile X Syndrome (FXS), epilepsy, and ASD