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This suggests that women with EMs may have dysfunctional immune responses to the refluxed endometrial fragments, preventing their clearance by the immune system and ultimately promoting inflammation, angiogenesis, and pathological conditions at the site of ectopic lesions ( 3.3 The role of EVs in the development of premature ovarian failure Premature Ovarian Failure (POF), now more commonly referred to as Primary Ovarian Insufficiency (POI), refers to the loss of ovarian function in women before the age of 40

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