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Weeks 25 and beyond: Maintenance and optimization At full maintenance doses, the rate of weight loss gradually slows as the body approaches a new equilibrium

The compound shows effectiveness across a wide dose range in animal studies (10 ng/kg to 10 mcg/kg producing comparable results), suggesting that more is not necessarily better

The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance