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Intestinal Toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia/reperfusion injury

Wink S, Hiemstra SW, Huppelschoten S, Klip JE, van de Water B

Although effective, these medications often present such side effects as skin rashes, fever, arthralgia, liver toxicity, and agranulocytosisan extreme decline in white blood cell count-that preclude their long-term use in certain patients (Mishra et al