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A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes
Centrally, cagrilintide crosses the blood-brain barrier and activates receptors in key hypothalamic regions including the arcuate nucleus, area postrema, and lateral parabrachial nucleus
To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)
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