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treatment of blood cells with lead resulted in ROS-independent eryptosis without any increase in ROS, but with an increase in Ca 2+ level and caspase-3 activity

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Studies in animals have also shown an anorexigenic effect of the GIP and in preclinical studies, the simultaneous activation of GLP-1 and GIP receptors leads to enhanced glucose-lowering effects and more WL compared to activating either receptor alone [21,38,39]