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It is also indirectly responsible for cystine uptake via the cystine/glutamate antiporter system that reduces to cysteine, another rate-limiting precursor in glutathione synthesis [12]

If patient is taking a beta-blockers for control of hypertension, it should be withheld for 24h before challenge, as these agents can interfere with treatment of anaphylaxis with epinephrine, should that be necessary