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2.1 LC3 adaptor protein and ubiquitin-dependent pathway Currently, research has identified five LC3 adaptor proteins, including sequestosome-1 (SQSTM1/P62), optineurin (OPTN), nuclear dot protein 52 (NDP52), TAX1 binding protein 1 (TAX1BP1), and neighbor of breast cancer susceptibility gene one protein (NBR1) (Stolz et al., 2014) (Figure 1A)

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While the addictive nature and health risks associated with nicotine, particularly from smoking, are well-documented, its potential benefits in neurology and cognitive enhancement provide a compelling area for further research