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Proper laboratory safety protocols must be followed when handling these research materials

Similarly, in LDL receptor knock-out mice subjected to a Western diet, treatment-reduced plaque lesions and semaglutide were reported to affect the expression of several genes related to cholesterol metabolism, leukocyte recruitment, adhesion and extravasation, and also extracellular matrix protein turnover [35]

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In human HF patients, myocardial biopsies reveal increased lipid peroxidation, mtDNA damage, and reduced SOD2 activity, which correlate with disease severity