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GSH is essential for cell survival as demonstrated by observations that glutamate cysteine ligase (GCL) knockout mice die from massive apoptotic cell death [117], and that the knockdown of GCL in distinct cell types induces time-dependent apoptosis [118,119]

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The next generation of nanomedicines should be designed to be safer, more selective, and more therapeutic, targeting the real degenerative triggers with reduced adverse effects (217)