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You should definitely consult your doctor before taking it if youre on any regular prescription medications. Here is a list of more medications that shouldnt be combined with milk thistle: Antipsychotics: Anecdotal evidence suggests that milk thistle may reduce the effectiveness of antipsychotic medication, such as haloperidol

Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination

508 Nicorandil, an ATP-sensitive K + channel opener, alleviates cardiac microvascular injury by improving microvascular perfusion and structural integrity

But long-term safety data is lacking