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Consequently, increased reactive oxygen species levels lead to decreased levels of reduced GSH and increased levels of TGF-, which has been demonstrated to inhibit the rate-limiting enzyme responsible for the de novo synthesis of GSH

According to published research, oral glutathione is the first choice among 52% of Indian dermatologists, and topical formulations with Vitamin C and Glutathione are widely advocated as a safe initial approach to gradual skin brightening, with visible benefits in 6-10 weeks

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However, considering that the human bodys endogenous antioxidant system is not sufficient, the human body can hardly produce nonenzymatic antioxidants, so it depends on exogenous nonenzymatic antioxidants, such as mineral elements, nutritional antioxidants, phytochemicals, cytoprotectants and synthetic compounds (Table 1) [34, 36]