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High absorption is often more important than simply increasing dosage

While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves

In the case of high autophagic flux, ferritin is degraded, releasing more Fe 2+ , which further promotes the Fenton reaction and lipid peroxidation, thereby exacerbating ferroptosis and causing greater membrane damage

Since the latter study had a placebo group which had redox and methylation biomarkers measured at the beginning and end of the intervention, we use this placebo group as a control group for all three studies in order to determine if the changes in redox and methylation metabolism were significant as a result of the three interventions