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The lock spray mass compound, MS leucine-enkephaline (an external reference to the ion m / z 556.2771 in positive mode and 554.2615 in negative mode), was constantly injected, which is responsible for switching between the sample and the reference for every 45 and 60 s in both modes, scan time was 0.5 s, the flow rate was 10 L/min, and collision energy was 4 V and 30 V for the cone, respectively

Unlike retinol, topical peptides such as GHK-Cu may work to upregulate both the breakdown and synthesis of collagen and other intercellular matrix components, thereby increasing collagen turnover [15]

This method is popular for its quick and noticeable results, especially when combined with other skin lightening treatments

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