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Originally engineered at Washington State University by the Harding lab and later licensed to M3 Biotechnology, Dihexa retains the angiotensin IV pharmacophore for AT4 receptor binding while incorporating N-hexanoyl and aminohexanoic acid modifications that confer metabolic stability and lipophilic BBB penetration

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The results revealed that Neuroactive ligand-receptor interaction and Calcium signaling pathway were the primary mechanisms through which this combination exerted synergistic effects

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