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Accutane is the brand name for isotretinoin , a powerful prescription medication primarily used to treat severe nodular or cystic acne that hasnt responded to other treatments like antibiotics or topical medications

Even though Tyr9 is not a base causing the unusual acidity of the thiol, it contributes to the mechanism as indicated by the low isomerase activity of the Tyr9Phe mutant, being only 2% of the wildtype activity (Pettersson and Mannervik, 2001)

The past three decades have guided us into this developing convergence

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