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Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

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[] While these metals do have essential biological functions, they are however needed only in miniscule amounts, and should an excessive intake of these metals occur or accumulate, their presence can result in cellular and tissue damage, which could result in disease and disorders among humans

Recent studies indicate that periodontal pathogens may contribute to gut dysbiosis and associated systemic diseases, highlighting a potential link between periodontitis and various non-oral conditions