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Cigarette smoking was called a significant factor in cancer of the larynx

Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 [accessed 2016 Mar 29]

241 However, based on FDA's current interpretation, user fees could not be collected from ENDS manufacturers and importers without first enacting authorizing legislation

Cigarette smoking can cause citrullination (a post-translation modification of the amino acid arginine) of proteins in the body which results in the production of anticyclic citrullinated protein antibodies that are strongly associated with the development of RA