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Highly disordered proteins can be readily recognized by CD, since they lack any significant organized secondary structure and therefore have a peculiar far-UV CD spectrum resembling that of an unordered polypeptide, with a strong negative band near 200 nm and either a weak negative shoulder or a weak positive maximum near 220 nm (Woody, 2010)

Administration routes included oral, intravenous and naso/orogastric routes with dose regimens ranging from 25 mg/kg to 140 mg/kg loading doses

CASPER: A phase I trial combining Calaspargase pegol-mnkl and Cobimetinib in pancreatic cancer