However, under oxidative stress conditions, Nrf2 dissociates from Keap1, accumulates in the cytoplasm, and is transported into the nucleus to bind to target genes
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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines
