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Additionally, lactate enters vascular endothelial cells via MCT1, which can activate the HIF-1 pathway and upregulate the expression of VEGFR2 and bFGF under normoxic conditions, promoting angiogenesis

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It achieves this feat by diminishing Bax while elevating the presence of the Bcl-2 associated agonist of cell death (Bad) protein in murine models, particularly DBA/2J mice, which serves as a representative model of diffused glaucoma

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