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The kinetic data were analyzed by using the GraphPad Prism software with a simple pseudo first-order reaction model to estimate the apparent kinetic parameters

Such approaches could better reflect real-world clinical practice and potentially demonstrate benefits that fixed-dose studies might miss

R After glutathione conjugation, the conjugate is further processed through the mercapturic acid pathway : gamma-glutamyl transpeptidase removes glutamate, then a dipeptidase removes glycine, leaving a cysteine conjugate that is N-acetylated to form a mercapturic acid (N-acetylcysteine conjugate)

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