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Because increasing age is the predominant risk factor for clinical Alzheimer's dementia, as the number and proportion of older Americans grows rapidly, so too will the numbers of new and existing cases of clinical Alzheimer's dementia, as shown in Figure 8.A5 , 276 By 2060, the number of people age 65 and older with clinical Alzheimer's dementia is projected to reach 13.8 million, barring the development of breakthroughs to prevent or cure Alzheimer's disease.A5 , 276 3.12.2

This mechanism increases nitric oxide production, which is essential for endothelial cell proliferation, vessel dilation, and new capillary formation