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TGR was also identified as a multifunctional oxidoreductase with a remarkably wide substrate specificity, capable of directly reducing peroxides, selenium-containing compounds, and several important low-molecular-weight antioxidants, as well as Trx, DTNB, GSSG, and GSH-HED

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Some bacterial species are directly associated with an increased or reduced risk for colon tumorigenesis, but for many, exact mechanisms are not yet elucidated