It also stimulates the overexpression of the transient receptor potential melastatin 2 (TRPM2) ion channels, triggering macrophage activation, leading to a systemic immune response
Srivastava, D., Ieda, M., Fu, J., & Qian, L
however, the optimal dosage and duration of supplementation have yet to be clearly established [61].A meta-analysis of studies evaluating formulas containing various immunonutrients, including arginine and fish oil, administered to high-risk patients undergoing elective surgery during the preoperative and postoperative periods found a significant reduction in infection rates and LOS, albeit without a difference in mortality [62]
And that's precisely why researchers are so intrigued by compounds that might support angiogenesis (the formation of new blood vessels) and cellular repair at a fundamental level