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Importantly, depending on the nature of the insult, quantity of anti-inflammatory feedback, and functional status of endogenous restoration mechanisms, perpetuation of this inflammatory cycle can either culminate in damage repair or in progression of chronic disease (Fig

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Peroxiredoxins Prxs are a ubiquitous family of antioxidant enzymes that regulate peroxide and peroxynitrite levels in mammalian cells (Sanchez-Font et al., 2003)