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Nestler JE, Singh R, Matt DW, Clore JN, Blackard WG

As germline LOXL2 knockout is lethal, the colony was generated by mating heterozygous mice

By combining in vitro experiments with inhibitors, gene silencing, functional assays, and transcriptomic data analysis, the researchers established a framework to uncover how Humanin might regulate insulin signaling, lipid metabolism, apoptosis, and mitochondrial function

Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells