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Mounting evidence suggests that ferroptosis plays an important role in cancer (Lei et al., 2022), neurodegenerative diseases (Ryan et al., 2022), and ischemia/reperfusion injury, such as acute kidney injury (Fan et al., 2022), acute myocardial infarction (Miyamoto et al., 2022), and hepatic ischemia-reperfusion injury (Ye et al., 2022a), and autoimmune disease, like psoriasis (Zhou et al., 2022) and rheumatoid arthritis (Long et al., 2022), Serving as the maternal-fetal interface, placenta plays a central role in maternal and fetal health during pregnancy

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In other words, GABA-aberrant glutamate interactions induce loss of synapses, but glutamate metabolic changes can also injure neurons excitotoxically [15]