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This article reviews: Definition Mechanism of action Experimentally observed benefits Dosages used in scientific studies Reported side effects in laboratory settings All references below relate to experimental or preclinical research models

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Peer review Peer review information Nature Medicine thanks the anonymous reviewers for their contribution to the peer review of this work

Many studies have investigated the TSH reference range in pregnancy, fertility, and assisted reproduction technologies (ART), for the large debate on TSH in these circumstances