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O-GlcNAcylation and neurodegeneration

When referring to the charge of stapled peptides, several studies have proven that the positive charge is significant for the first step of cell internalization, as it provides electrostatic interactions with the negatively charged cell membrane, while peptides with negative charges rarely penetrate the membrane components, and in the presence of peptides with an NC ranging from 0 to +2, the permeation is more advantageous [98, 108, 134, 164166]

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