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In addition, the retrospective design, lack of diversity in our patient population, and single-center and single-arm design make additional validation of these data important

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Chord Concave Functions A function g(x) is called concave on an interval if, for any two points g(\lambda x_1 + (1-\lambda) x_2) \geq \lambda g(x_1) + (1-\lambda) g(x_2) This implies the graph of the function lies above or on the line segment joining any two points indicating downward curvature