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DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

173 However, it is important to note at least two studies have found no relationship between folate intake, blood folate levels, MTHFR mutations, and assisted reproductive outcomes

The 200-fold-greater potency of LR3 versus insulin in cell-culture systems coupled with the molecules resistance to enzymatic degradation in serum-free media underlies its adoption as a substitute for native IGF-1 in animal-component-free cell-culture protocols