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However, certain medications can affect its efficacy

Some medicines can decrease the absorption of vitamin B12, let your doctor know all other medicines you are taking to make sure you are safe

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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations