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10.1186/s13148-023-01555-0 172 WasserkortR.KalmarA.ValczG.SpisakS.KrispinM.TothK.et al (2013)

As a homologous enzyme of ACE, ACE2 is found in the hippocampus and cerebral cortex that cleaves Ang II to produce Ang-(17), which activates the Mas receptor and produces an inverse regulation of the ACE/Ang II/AT1 pathway ( 3 The relationship between RAS and depression/anxiety In addition to the systemic RAS, all the components of the RAS independently exist in the brain involving the pathophysiology of depression and anxiety

3 While results vary and more research is needed, these microbial therapies also often relieve gastrointestinal symptoms such as bloating and diarrhea, especially in patients with coexisting Irritable Bowel Syndrome

Pharm Res 32 , 26782689 (2015)