Regarding the repurposing of drugs for SCA3 that have positive preclinical data, caffeine likely has a benign course with chronic administration, but can eventually lose effect due to desensitization as previously reported [267]
Importantly, AOD9604 achieved these effects without activating the growth-promoting pathways that full-length growth hormone uses, which is why it doesnt cause the unwanted side effects of growth hormone therapy such as insulin resistance or abnormal growth
Factors that determine timing to return to sport include type of surgery performed (meniscectomy, repair or transplant), tear pattern, tissue quality, health and activity level of the patient, physical and psychological readiness
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